In 1970, Maine Medical Center (MMC) became a major clinical teaching center for Tufts University School of Medicine (TUSM), a relationship which lasted through July of 1980. Between 1980 and 2011, MMC was the principal affiliate of the University of Vermont College of Medicine - with third-year clerks training in all the major MMC clinical departments. In 2008, MMC and TUSM signed an agreement to collaborate in delivering a unique and innovative medical school curriculum aimed at helping address access and workforce needs in the State of Maine.

TUSM, in partnership with MMC, offers the Maine Track program for applicants who are interested in an innovative curriculum that offers clinical training experiences in Maine and exposes medical students to the unique aspects of rural practice as well as training at major tertiary medical center. Both TUSM and MMC are aggressively pursuing support that will allow Maine Track students to attend medical school without unusual financial hardship. Grant support, philanthropy, and state funding continues to be sought to subsidize tuition for Maine Track students, with the goal of reducing the tuition to a level comparable to in-state tuition at a regional medical school within a public university. To date, twenty $25,000 scholarships have been established and are awarded each year to incoming students.

All applicants with an interest in the practice of rural medicine or a desire to practice in Maine are encouraged to apply. Graduates of the program will receive a combined diploma from TUSM and MMC with the hope that many will establish medical practice in Maine.