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Births of Triplets, Quadruplets on Decline in U.S.: Report

Improvements in infertility treatments led to fewer risky multiple births by 2014, experts say

By Randy Dotinga
HealthDay Reporter

THURSDAY, April 28, 2016 (HealthDay News) -- Since 1998, births of three or more babies at once have fallen by more than 40 percent in the United States, new government statistics reveal.

Moreover, declines of 50 percent or more were seen in certain states, and among women aged 25 and older, according to the report from the U.S. Centers for Disease Control and Prevention's National Center for Health Statistics (NCHS).

The falloff appears to be connected to changes in infertility treatments, which result in multiple births far less often now compared with the 1980s and 1990s, experts said.

"This is a very positive development because the risk for moms and babies will be lower," said Dr. Tomer Singer. He is director of reproductive endocrinology and infertility at Lenox Hill Hospital in New York City.

"We'll have healthier babies born closer to term and fewer health complications related to prematurity -- like lung disease, heart disease and infections," said Singer, who wasn't involved with the new study.

For the report, Joyce Martin of the NCHS and colleagues examined birth statistics in 46 states and Washington, D.C., from 1998 to 2014.

The researchers found the rate of births of triplets, quadruplets or more babies fell 41 percent -- from 7,625 in 1998, when such births peaked, to 4,526 in 2014, reaching a rate of one in every 880 births.

In seven states -- Connecticut, Illinois, Massachusetts, Minnesota, New Hampshire, New Jersey and Rhode Island -- the rate of these births fell by at least half, the study findings showed.

One doctor welcomed the new numbers.

"Hopefully, this trend will continue," said Dr. Jennifer Kawwass, an assistant professor with the Emory Reproductive Center in Atlanta.

Kawwass said advances in in vitro fertilization (IVF) have helped stem multiple births.

"The trend toward reducing the number of embryos transferred and transferring a single embryo when possible during IVF cycles is moving in the right direction," she said. "Reproductive endocrinologists are making a conscious effort to continue improving."

Singer said most twins do fine, but higher-number multiples face unique medical challenges. When a woman has three or more embryos, some often don't survive pregnancy, he explained. They die because of abnormalities or because they are aborted for medical or financial reasons, he said.

Those who survive pregnancy are more likely to be premature, suffer from a variety of illnesses or die in their first year, Singer added.

According to the new report, 7 percent of triplets, quadruplets and higher multiple-births born in 2013 didn't live past one year, compared to one in 200 singletons (less than 1 percent).

Singer explained that as treatment moved from artificial insemination -- in which sperm is injected into a womb -- to IVF in a lab, doctors gained more control over the number of eggs fertilized.

Also, he agreed that IVF physicians now transfer fewer embryos into the womb, lowering the risk of multiple births. Given the widespread use of IVF, this make a difference, he said.

"We have more than 200,000 women going through [IVF] on an annual basis in the U.S. alone," Singer said.

The declines in births of three or more babies at once were highest among white women. Rates were lower for Hispanics and unchanged for blacks, the report found.

Dr. Evan Myers, professor of obstetrics and gynecology at Duke University Medical Center, said this may reflect lower numbers of black women undergoing costly infertility treatments. Blacks were less likely than whites to have health insurance, at least before the Affordable Care Act, and tend to have lower incomes, he said. That's an important consideration for those whose insurance doesn't cover infertility treatment, Myers added.

The report is published in the April issue of the NCHS Data Brief.

More information

The U.S. Centers for Disease Control and Prevention has more about assisted reproductive technology.


SOURCES: Tomer Singer, M.D., director, reproductive endocrinology and infertility, Lenox Hill Hospital, New York City; Evan Myers, M.D., M.P.H., professor, department of obstetrics and gynecology, Duke University Medical Center, Durham, N.C.; Jennifer Kawwass, M.D., assistant professor, Emory Reproductive Center, and director, third party reproduction, Emory Reproductive Center, Atlanta; April 28, 2016, U.S. National Center for Health Statistics, NCHS Data Brief, "Declines in Triplet and Higher Order Multiple Births in the United States, 1998-2014"

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